Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential

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Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential

The recent identification of progenitor populations that contribute to the developing heart in a distinct spatial and temporal manner has fundamentally improved our understanding of cardiac development. However, the mechanisms that direct atrial versus ventricular specification remain largely unknown. Here we report the identification of a progenitor population that gives rise primarily to card...

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Background & Aims: Myocardial infarction is a leading cause of human mortality in industrialized and developing societies. Limited restorative ability of of cardiomyocytes after ischemic changes can causes extensive damage lead to prominent chronic heart failure. At present, the application of certain drugs is touted as one of the main available approaches to inhibit the spread of the lesion an...

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To whom correspondence should be addressed: Zhong Wang, Cardiovascular Research Center, Massachusetts General Hospital, Harvard Stem Cell Institute, 185 Cambridge Street, Boston, MA 02114, USA. ([email protected]); Mai Har Sham, Department of Biochemistry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong. ([email protected])

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ژورنال

عنوان ژورنال: Nature Communications

سال: 2017

ISSN: 2041-1723

DOI: 10.1038/ncomms14428